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目的对４７例慢性乙型肝炎、肝炎肝硬化与散发性戊型肝炎重叠感染及５０例慢性乙肝进行临床对比分析，以探讨双重感染的临床特征、重症肝炎发生率及转归。方法采用ＥＬＩＳＡ法及ＥＩＡ法检测甲乙丙丁戊与５种肝炎病毒，同时检测肝功能（ＳＢ、ＡＬＴ、ＡＳＴ、Ａ／Ｇ、ＰＴ）。结果在ＨＢＶ感染的基础上重叠ＨＥＶ感染时，临床症状加重，深度黄疸的发生率高，血清白蛋白减低明显，凝血酶原时间明显延长，病情恢复慢，重症肝炎发生率高，病死率亦高。结论提示ＨＢＶ与ＨＥＶ重叠感染肝细胞损害加重，病情有重症化倾向。
Objective To compare 47 cases of chronic hepatitis B, hepatitis cirrhosis and sporadic hepatitis E overlap infection and 50 cases of chronic hepatitis B to explore the clinical features of double infection, the incidence and severity of severe hepatitis. Methods ELISA and EIA were used to detect methotrexate and five kinds of hepatitis viruses, and liver function (SB, ALT, AST, A / G, PT) were detected simultaneously. Results When HEV infection was superimposed on the basis of HBV infection, clinical symptoms were aggravated. The incidence of deep jaundice was high, the serum albumin was significantly reduced, the prothrombin time was prolonged, the condition was slowed down, the incidence of severe hepatitis was high, and the case fatality rate was also high . Conclusions HBV and HEV overlap infection liver cell damage worse, the disease has a tendency to severe.