论文部分内容阅读
目的:探讨中心性肥胖对不同糖代谢人群胰岛β细胞功能的影响。方法:146例中心性肥胖者根据血糖水平分为正常糖耐量(NGT组)50例、糖调节受损(IGR组)50例和T2DM组46例。并选取50例无中心性肥胖且正常糖耐量者为对照组(NC组)。所有受试者均检测空腹血游离脂肪酸(FFA)水平,并行口服葡萄糖耐量试验(OGTT),计算胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)和早期胰岛素分泌指数(△I_(30)/△G_(30))。分析中心性肥胖对不同糖耐量人群胰岛β细胞功能的影响。结果:NGT、IGR和DM 3组间△I_(30)/△G_(30)呈逐渐下降趋势(P<0.05),且NGT组△I_(30)/△G_(30)高于NC组(P<0.05)。4组间HOMA-IR呈逐渐上升趋势(P<0.05)。4组间FFA呈升高趋势,其中DM组明显高于NC组(P<0.05)。相关分析表明,腰围与HOMA-IR呈正相关(r=0.536,P<0.01)。结论:中心性肥胖对不同糖耐量人群胰岛β细胞功能影响各不相同。在正常糖耐量阶段,中心性肥胖者早期胰岛素分泌功能代偿性增加,随着血糖水平升高,这种代偿功能逐渐降低。
Objective: To investigate the effect of central obesity on pancreatic β-cell function in different glycometabolism population. Methods: A total of 146 patients with central obesity were divided into two groups according to their blood glucose levels: normal glucose tolerance (NGT group) 50 cases, impaired glucose regulation (IGR group) 50 cases and T2DM group 46 cases. Fifty patients without central obesity and normal glucose tolerance were selected as the control group (NC group). All subjects were tested for fasting blood free fatty acid (FFA) level, parallel oral glucose tolerance test (OGTT), calculation of insulin resistance index (HOMA-IR), insulin secretion index (HOMA-β) and early insulin secretion index (△ I_ (30) / ΔG_ (30)). Analysis of the effect of central obesity on islet β cell function in different glucose tolerance population. Results: The △ I_ (30) / △ G_ (30) showed a decreasing trend (P <0.05) in NGT, IGR and DM 3 groups, and the △ I_ (30) / △ G_ (30) P <0.05). HOMA-IR showed a gradual upward trend among the four groups (P <0.05). FFA showed an increasing trend among the four groups, of which the DM group was significantly higher than the NC group (P <0.05). Correlation analysis showed that waist circumference was positively correlated with HOMA-IR (r = 0.536, P <0.01). CONCLUSION: Central obesity has different effects on pancreatic β-cell function in different glucose tolerance populations. In normal glucose tolerance stage, central insulin obesity early compensatory increase in insulin secretion, as blood glucose levels, this compensatory function gradually decreased.