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目的 探讨原发性肝癌患者的血硒水平与其病理类型、临床分期和肝内转移的相互关系。方法 采用 2 ,3 -二氨基萘荧光分析法测定 10 4例原发性肝癌患者和 74例正常人的血硒水平。结果 原发性肝癌患者和正常人的血硒水平分别为 ( 0 .113± 0 .0 2 5 )mg/L ,( 0 .13 0± 0 .0 2 3 )mg/L ,两者有非常显著性差异 (P <0 .0 1)。巨块型和结节型原发性肝癌患者的血硒水平分别为( 0 .12 7± 0 .0 3 2 )mg/L ,( 0 .0 98± 0 .0 17)mg/L ,前者与正常人比较无显著性差异 (P >0 .0 5 ) ,后者则有非常显著性差异 (P <0 .0 1)。Ⅰ、Ⅱ、Ⅲ期原发性肝癌患者的血硒水平均显著低于正常人 (P值分别 <0 .0 1,0 .0 5 ,0 .0 1) ,但彼此间比较无显著性差异 (P >0 .0 5 )。肝外转移者的血硒水平亦低于正常人 (P <0 .0 1)。结论 巨块型肝癌患者的血硒水平与正常人比较无显著性差异 ,但结节型与正常人比较则有非常显著性差异 ,提示肝癌患者的血硒水平可能与病理类型相关。Ⅰ、Ⅱ、Ⅲ期肝癌患者的血硒水平均低于正常人 ,但彼此间比较无显著性差异 ,提示肝癌患者的血硒水平与临床分期可能无相关性。巨块型肝癌患者血硒水平的升高可能与其肝内转移有关。
Objective To investigate the relationship between blood selenium level and pathological type, clinical stage and intrahepatic metastasis in patients with primary liver cancer. Methods Selenium levels in 104 patients with primary hepatocarcinoma and 74 normal controls were determined by 2, 3 - diaminonaphthalene fluorescence analysis. Results Selenium levels in patients with primary liver cancer and normal people were (0.113 ± 0. 025) mg / L, (0.13 0 ± 0. 023) mg / L respectively, Significant difference (P <0. 01). The selenium levels in patients with massive and nodular primary liver cancer were (0.127 ± 0.302) mg / L and (0.098 ± 0.17) mg / L, respectively There was no significant difference between the two groups (P> 0.05), while the latter had a very significant difference (P <0.01). Selenium levels in patients with primary liver cancer in stages I, II, and III were significantly lower than those in controls (P <0.010,0.050,0.01, respectively), but not significantly different from each other (P> 0.05). Blood selenium levels in those with extrahepatic metastases were also lower than those in normal subjects (P <0.01). Conclusion There is no significant difference in blood selenium level between patients with massive liver cancer and normal people, but there is a significant difference between nodules and normal people, suggesting that selenium levels in patients with liver cancer may be related to pathological types. Selenium levels in patients with stage I, II and III liver cancer were lower than those in normal people, but there was no significant difference between them, suggesting that selenium levels in patients with liver cancer may not correlate with clinical stage. The blood level of selenium in patients with massive liver cancer may be related to the intrahepatic metastasis.