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本文对９３８例初生婴儿接种小剂量（１０ｕｇ×３）乙肝疫苗后３－５年的预防效果进行了随访观察，并以２５３例初生儿未接种疫苗者作为对照，结果表明，接种组３－５年后抗－ＨＢｓ阳性率显著高于对照组，ＨＢｓＡｇ阳性率则较对照组显著为低。感染保护率８６．７％。结果还表明，接种乙肝疫苗３年后加强１次，比不加强者Ｐ／Ｎ均值显著增高。文章认为初生儿接种小剂量乙肝疫苗有长期免疫效果；接种后３年加强接种１次，可保持较高免疫力。
In this paper, 938 cases of newborn infants vaccinated with small doses (10ug × 3) of hepatitis B vaccine 3-5 years follow-up observation of the prevention effect, and 253 cases of unvaccinated neonates as a control, the results show that inoculation group 3-5 Years after anti-HBs positive rate was significantly higher than the control group, HBsAg positive rate was significantly lower than the control group. Infection protection rate of 86.7%. The results also show that vaccination of hepatitis B vaccine after 3 years to strengthen once, than those who do not strengthen the P / N mean significantly higher. The article believes that low doses of hepatitis B vaccination of newborns with long-term immunization effect; three years after vaccination to strengthen vaccination 1, to maintain a high immunity.