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目的研究白细胞提取物（ＬＥ）的抗炎作用。方法用角叉菜胶和弗氏完全佐剂分别诱导大鼠的急、慢性炎症模型。结果ＬＥ（０．１５，０．７５ｍｇ·ｋｇ－１·天－１，０～３天ｓｃ）对角叉菜胶诱导的大鼠急性炎症反应有明显的抑制作用，ＬＥ（０．１５，０．７５ｍｇ·ｋｇ－１·天－１，０～２７天，ｓｃ）对佐剂性关节炎（ＡＡ）大鼠１２天、１６天、２０天、２４天、２８天继发炎症反应亦有明显的抑制作用，还可明显减轻ＡＡ大鼠非致炎侧膝和踝关节病理组织学变化。结论ＬＥ对急、慢性炎症模型均有抗炎作用
Objective To study the anti-inflammatory effect of leukocyte extract (LE). Methods Carrageenan and Freund’s complete adjuvant were used to induce acute and chronic inflammation in rats. Results LE (0.15,0.75 mg · kg-1 · day -1 and 0 ~ 3 days sc) significantly inhibited carrageenan-induced acute inflammation in rats. LE (0.15,0 .75mg · kg-1 · day-1, 0 ~ 27days, sc) had obvious secondary inflammation in rats of adjuvant arthritis (AA) at 12, 16, 20, 24 and 28 days , But also significantly alleviate the histopathological changes of non-inflammatory side knees and ankles in AA rats. Conclusion LE has anti-inflammatory effects on acute and chronic inflammatory models