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目的研究妊娠期高血压应用拉贝洛尔联合硫酸镁治疗的有效性。方法选择来自我院2014年2月-2015年12月妊娠期高血压患者80例。将其随机分为硫酸镁组和联合用药组。硫酸镁组仅给予硫酸镁治疗,联合用药组应用拉贝洛尔联合硫酸镁治疗。比较两组患者剖宫产率、产后出血率、新生儿窒息率;用药前和用药后患者平均动脉压、心率的差异。结果联合用药组相较于硫酸镁组剖宫产率、产后出血率、新生儿窒息率更低(P<0.05);用药前两组平均动脉压、心率相似(P>0.05);用药后联合用药组相较于硫酸镁组平均动脉压、心率改善更显著(P<0.05)。结论妊娠期高血压应用拉贝洛尔联合硫酸镁治疗的有效性高,可有效改善临床症状和母婴结局,值得推广。
Objective To study the efficacy of labetalol combined with magnesium sulfate in the treatment of gestational hypertension. Methods Eighty patients with hypertensive disorder during pregnancy from February 2014 to December 2015 in our hospital were selected. They were randomly divided into magnesium sulfate group and combination group. Magnesium sulfate group only given magnesium sulfate treatment, combination therapy group with labetalol combined with magnesium sulfate treatment. The cesarean section rate, postpartum hemorrhage rate and neonatal asphyxia rate were compared between two groups. The difference of mean arterial pressure and heart rate before and after treatment were compared. Results The cesarean section rate, postpartum hemorrhage rate and neonatal asphyxia rate in the combination group were lower than those in the magnesium sulfate group (P <0.05). The mean arterial pressure and heart rate in the two groups before treatment were similar (P> 0.05) Compared with the mean arterial pressure in the magnesium sulfate group, the heart rate improved more significantly (P <0.05). Conclusion The application of labetalol combined with magnesium sulfate in the treatment of hypertension in pregnancy has high efficacy, which can effectively improve clinical symptoms and maternal and infant outcomes and is worth promoting.