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目的探讨加巴喷丁治疗带状疱疹后遗神经痛患者的临床疗效。方法选取2013年10月至2015年10月辽宁省抚顺市中心医院收治的98例带状疱疹后遗神经痛患者为研究对象,随机将其分为研究组和对照组,各49例。研究组患者采用加巴喷丁治疗,对照组患者采用布洛芬胶囊治疗,比较两组患者临床疗效、睡眠时间、疼痛程度及不良反应发生情况。结果研究组患者的治愈率和治疗的总有效率均明显高于对照组,差异均有统计学意义(均P<0.05);治疗后,研究组患者睡眠时间明显长于对照组,差异有统计学意义(P<0.05);治疗后,研究组患者疼痛视觉模拟量表(VAS)评分明显低于对照组,差异有统计学意义(P<0.05);研究组患者不良反应发生率明显低于对照组,差异有统计学意义(χ~2=9.375,P<0.05)。结论对于带状疱疹后遗神经痛患者采用加巴喷丁治疗效果较好,不仅可以有效提高治愈率、睡眠质量,还可有效缓解疼痛,且安全性较高。
Objective To investigate the clinical efficacy of gabapentin in the treatment of postherpetic neuralgia patients. Methods A total of 98 patients with postherpetic neuralgia admitted to Fushun Central Hospital from October 2013 to October 2015 were randomly divided into study group and control group, with 49 cases in each group. Patients in the study group were treated with gabapentin, while those in the control group were treated with ibuprofen. The clinical efficacy, sleep time, degree of pain and incidence of adverse reactions were compared between the two groups. Results The cure rate and total effective rate of treatment group were significantly higher than that of control group (all P <0.05). After treatment, the sleep time of study group was significantly longer than that of control group, the difference was statistically significant (P0.05) .After treatment, the pain visual analog scale (VAS) score of study group was significantly lower than that of control group, the difference was statistically significant (P0.05); the incidence of adverse reactions in study group was significantly lower than that of control group Group, the difference was statistically significant (χ ~ 2 = 9.375, P <0.05). Conclusion GABA treatment for postherpetic neuralgia patients is better, which not only can effectively improve the cure rate, sleep quality, but also relieve the pain effectively and have higher safety.