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目的深入了解药源性进行性多灶性白质脑病的病因及风险因素,实现对风险药物及药源性疾病的有效控制。方法对进行性多灶性白质脑病的病原学基础、发病机制、药物相关性的风险因素、以及相应的风险管理实践进行了分析和梳理。结果 JC病毒感染是发生药源性进行性多灶性白质脑病的病原学基础,免疫功能受损患者是易感人群,长期及多种免疫抑制剂或免疫调节剂使用可增加药源性进行性多灶性白质脑病的风险。结论合理的风险控制措施可有效控制不同风险级别药品进行性多灶性白质脑病的发生风险。我国相关病例报告较少,仍需要加强监测,提高风险控制能力。
Objective To understand the etiopathogenisis and risk factors of drug-induced progressive multifocal encephalopathy and to achieve effective control of risk drugs and drug-induced diseases. Methods The pathogenic basis, pathogenesis, drug-related risk factors of progressive multifocal leukoencephalopathy and corresponding risk management practices were analyzed and combed. Results JC virus infection was the etiological basis of drug-induced progressive multifocal leukoencephalopathy. Patients with impaired immune function were susceptible, and long-term and multiple immunosuppressive agents or immunomodulators could increase the drug-induced progressive Risk of multifocal leukoencephalopathy. Conclusion The reasonable risk control measures can effectively control the risk of multifocal leukoencephalopathy in patients with different risk levels. Relatively few reports of related cases in our country still need to strengthen the monitoring and improve the risk control ability.