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急性肾功能衰竭是磷烧伤患者的主要死亡原因之一,其发生机制迄今尚未阐明。本研究采用光镜、电镜观察和立体计量、放射性生物微球、免疫组化,放射自显影、单免扩散、放免分析、墨汁-明胶灌注、体外组织培养等多种方法,系统地研究了大鼠磷烧伤后肾脏,尤其是肾小球形态、功能和血流的病理变化,病变特点、病变间相互关系;研究了肾小球内纤维连接蛋白(Fibronectin,Fn)的分布、来源及
Acute renal failure is one of the major causes of death in patients with phosphorus burn, the mechanism has not yet been elucidated. In this study, many methods such as light microscopy, electron microscopy and stereological measurement, radioactive biological microspheres, immunohistochemistry, autoradiography, single diffusion-free, radioimmunoassay, ink-gelatin perfusion and in vitro tissue culture were systematically investigated. The pathological changes, pathological features and pathological changes of kidney, especially glomerular morphology, function and blood flow after rat phosphorus phosphorus burn were studied. The distribution and origin of Fibronectin (Fn) in glomeruli were studied