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纳洛酮为吗啡拮抗剂。已有报道用于治疗败血症性休克、低血容量性休克、酒精引起的昏迷和脊髓外伤。Baskin 等报道2例蛛网膜下腔出血并发偏瘫病人,用纳洛酮5分钟内症状好转,但只维持不到20分钟。作者对脑出血、脑血栓形成和脑梗塞而出现神经症状在3—24小时内的13例病人进行了单盲法研究。首次静脉注2ml 盐水,观察10分钟后,静注纳洛酮0.8mg—1.2mg,每隔10分钟进行一次神经系统检查。结果:注入盐水后无反应,静注纳洛酮后13例病人中有3例神经症状明显改善。一例是脑干梗塞,给0.4mg 纳洛酮2分钟内,旋转性眼颤消失,眩晕和轻瘫肢体肌力好转,并持续20分钟,第2天用同样剂量再次好转。一例证实是右大脑中动脉分布区呈低密度,给纳洛酮0.4mg,5分钟内左侧偏瘫肯定改善,持续15分钟,一小时后给同样剂量出现同样反应。一例给纳洛酮15分钟后,症状明显
Naloxone is a morphine antagonist. It has been reported for the treatment of septic shock, hypovolemic shock, alcohol induced coma and spinal cord injury. Baskin and other reports of 2 cases of subarachnoid hemorrhage complicated with hemiplegia patients with naloxone within 5 minutes to improve the symptoms, but only less than 20 minutes. The authors conducted a single-blind study of 13 patients who developed neurological symptoms of cerebral hemorrhage, cerebral thrombosis, and cerebral infarction within 3-24 hours. The first intravenous infusion of 2ml saline, observed 10 minutes after intravenous injection of naloxone 0.8mg-1.2mg, once every 10 minutes a neurological examination. RESULTS: There was no response after saline injection, and neurological symptoms were significantly improved in 3 of 13 patients intravenously injected with naloxone. One case was a brainstem infarction. Within 2 minutes of 0.4 mg naloxone, the rotational nystagmus disappeared and the dizziness and paresis limb muscle strength improved for 20 minutes. On the second day, the same dose was taken again. An example is confirmed that the distribution of the right middle cerebral artery was low density to naloxone 0.4mg, left hemiplegia within 5 minutes certainly improved for 15 minutes, one hour after the same dose to the same response. A case of naloxone 15 minutes after the obvious symptoms