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吸烟对脂蛋白代谢的影响过去的三十年间,日本的吸烟率虽已逐步下降,但年龄在20岁以上的男性有60%以上吸烟。这样就使日本的吸烟率列工业化国家之首。最近年轻人吸烟增多,患心肌梗塞的也随之增多,其中有些人才30岁。众所周知动脉粥样硬化与脂蛋白代谢异常关系密切,而吸烟被认为会直接或间接加重动脉粥样硬化。Bradley等报道:吸烟的女性中高密度脂蛋白(HDL)胆固醇的降低与吸烟包数有关(一包烟20支)。非吸烟者HDL胆固醇为63.7±16.8mg/dl,而每天吸烟超过两包者该值可低到56.9±16.3 mg/dl。Hully等进行了两年的多种危险因素干预试验,观察血清硫氰酸盐和HDL胆固醇之间的关系。作为吸烟者生化指标的
The Impact of Smoking on Lipoprotein Metabolism Although the prevalence of smoking in Japan has been declining over the past three decades, more than 60% of men aged 20 and over smoke have smoked. This led to Japan’s smoking rate ranks first in the industrialized countries. The recent increase in young people smoking, myocardial infarction have also increased, some of whom are 30 years old. It is well-known that atherosclerosis is closely linked to the abnormal metabolism of lipoproteins, whereas smoking is thought to directly or indirectly aggravate atherosclerosis. Bradley et al. Reported that the decrease in high-density lipoprotein (HDL) cholesterol in smokers was related to the number of packs (20 cigarettes). Non-smokers had HDL cholesterol of 63.7 ± 16.8 mg / dl, while those who smoked more than two packs a day had values as low as 56.9 ± 16.3 mg / dl. Hully et al conducted a two-year trial of various risk factors to observe the relationship between serum thiocyanate and HDL cholesterol. As a biochemical indicators of smokers