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目的探究冻干重组人脑利钠肽(新活素)治疗急性心肌梗死合并心力衰竭的效果。方法 52例急性心肌梗死合并心力衰竭患者按照住院号的奇偶数分为对照组和治疗组,各26例。对照组采取常规治疗,治疗组在对照组基础上加用新活素治疗。对比两组患者治疗前后的心率、血压、左心室射血分数(LVEF)、氨基末端B型脑钠肽前体(NT-proBNP)以及临床疗效等。结果治疗后,两组心率、血压、NT-proBNP、LVEF均有所改善,且治疗组优于对照组,差异具有统计学意义(P<0.05)。治疗组总有效率为96.2%,显著高于对照组的73.1%(P<0.05)。结论临床上利用新活素治疗急性心肌梗死合并心力衰竭效果明显,可以有效改善患者心功能指标,且无明显的不良反应,值得临床推广应用。
Objective To investigate the effect of lyophilized recombinant human brain natriuretic peptide (NSAID) in the treatment of acute myocardial infarction complicated with heart failure. Methods Fifty-two patients with acute myocardial infarction complicated by heart failure were divided into control group and treatment group according to the number of hospitalization, each with 26 cases in each group. Control group to take conventional treatment, the treatment group in the control group based on the use of new survivin treatment. The heart rate, blood pressure, left ventricular ejection fraction (LVEF), NT-proBNP and clinical efficacy were compared before and after treatment. Results After treatment, the heart rate, blood pressure, NT-proBNP and LVEF were improved in both groups, and the treatment group was superior to the control group. The difference was statistically significant (P <0.05). The total effective rate was 96.2% in the treatment group, which was significantly higher than 73.1% in the control group (P <0.05). Conclusions The clinical use of neomycin is effective in the treatment of acute myocardial infarction complicated with heart failure, which can effectively improve the cardiac function index of patients with no obvious adverse reactions and is worthy of clinical application.