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目的为研究表皮生长因子受体（ＥＧＦＲ）、转化生长因子α（ＴＧＦ┐α）与卵巢癌发生、发展的关系。方法用原位杂交法研究了ＥＧＦＲ、ＴＧＦ┐α、ＥＧＦｍＲＮＡ在７２例卵巢肿瘤及正常卵巢组织中的表达。结果ＴＧＦ┐α在卵巢癌中的检出率为５７．８９％。在良性肿瘤、交界性肿瘤和正常卵巢组织中的检出率分别为２０．００％、３３．３３％和１６．６７％。各组与卵巢癌组间均有显著差异（Ｐ＜０．０５）。ＥＧＦＲ在上述组中的表达率分别为６５．７９％、２０．００％、３３．３３％和２５．００％，后三者与卵巢癌组间有显著差异（Ｐ＜０．０５）。ＴＧＦ┐α和ＥＧＦＲ在各期卵巢癌中的表达率分别为：Ｉ期１２．５％和５０．００％、Ⅱａ、ｂ期；７０．５９％、５８．８２％、Ⅱｃ～Ⅳ期：６９．２３％和４６．１５％，ＥＧＦ在上述各类组织中极少表达。结论ＴＧＦ┐α和ＥＧＦＲ在卵巢肿瘤中有高水平的表达，且临床分期越晚，恶性程度越高，表达率越高，提示ＴＧＦ┐α／ＥＧＦＲ自分泌系统在卵巢癌的发生发展起着重要的作用，而ＥＧＦ／ＥＧＦＲ这一系统可能不发挥作用。
Objective To study the relationship between epidermal growth factor receptor (EGFR), transforming growth factor-α (TGFαα) and the occurrence and development of ovarian cancer. Methods The expression of EGFR, TGFαα and EGFmRNA in 72 ovarian tumors and normal ovarian tissues was studied by in situ hybridization. Results The positive rate of TGFαα in ovarian cancer was 57.89%. The positive rates in benign tumors, borderline tumors and normal ovarian tissues were 20.00%, 33.33% and 16.67%, respectively. There was significant difference between each group and ovarian cancer (P <0.05). The expression rates of EGFR in the above groups were 65.79%, 20.00%, 33.33% and 25.00%, respectively. There was significant difference between the latter three groups and the ovarian cancer group (P <0.05). The expression rates of TGFαα and EGFR in all stages of ovarian cancer were 12.5% and 50.00% in stage Ⅰ, Ⅱa and b stage, 70.59% and 58.82% in stage Ⅰc-Ⅳ .23% and 46.15% respectively. EGF was seldom expressed in the above tissues. Conclusions TGFαα and EGFR are highly expressed in ovarian neoplasms. The later clinical stage, the higher the malignant degree, the higher the expression of TGFαα and EGFR, suggesting that the TGFαα / EGFR autocrine system plays an important role in the development of ovarian cancer The role of EGF / EGFR system may not play a role.