论文部分内容阅读
目的 观察兔脑外伤后应用复方丹参 (SMC)对脑血流速度 (BFV)和脑水肿变化的影响 ,为临床上脑外伤后早期应用复方丹参提供参考。方法 2 0只兔均分为A(对照组 )和B(治疗组 )二组。治疗组 (B)采用复方丹参静脉注射 ,A组同样方法应用等量无菌生理用水。以大脑中动脉血流速度 (Vmca)和脑组织含水量作为观察指标。结果 致伤后第 1天 ,A、B二组Vmca明显下降 ,第 2、3、4天A组Vmca分别为 ( 1 9 1± 4 3)cm/s,( 1 7.9± 4.9)cm/s,( 1 9.7± 4.5)cm/s。B组分别为 ( 2 5 6± 4 6)cm/s,( 2 4 .5± 4.5)cm/s,( 2 5.8± 4.5)cm/s。A、B二组兔脑组织含水量百分比分别为 81 76± 0 53和 79 0 5± 0 54,B组治疗后Vmca高于A组 ,脑含水量低于A组 (P <0 0 5)。结论 复方丹参可改善兔早期脑外伤后的低血流速度 ,降低脑水肿程度
Objective To observe the effect of compound salvia miltiorrhiza (SMC) on changes of cerebral blood flow velocity (BFV) and cerebral edema after traumatic brain injury in rabbits, and to provide reference for the early application of compound salvia miltiorrhiza in clinical traumatic brain injury. Methods Twenty rabbits were divided into two groups: A (control group) and B (treatment group). The treatment group (B) was intravenously injected with Compound Danshen, and the same method used in group A was applied with the same amount of sterile physiological water. The middle cerebral artery blood flow velocity (Vmca) and brain tissue water content were used as observation indexes. Results On the first day after injury, Vmca in group A and group B decreased significantly. On day 2, 3, and 4 of group A, Vmca was (1 9 1 ± 4 3) cm/s, (1 7.9± 4.9) cm/s. , (1 9.7 ± 4.5) cm/s. Group B was (256 ± 46) cm/s, (24.5 ± 4.5) cm/s, (25.8 ± 4.5) cm/s. The percentage of water content in brain of rabbits in groups A and B was 81 76 ± 0 53 and 79 0 5 ± 0 54. After treatment, Vmca was higher in group B than in group A, and the brain water content was lower than that in group A (P <0 05). . Conclusion Compound salvia miltiorrhiza can improve the low blood flow velocity and reduce brain edema after brain injury in rabbits.