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目的:阐明鲎细胞溶解物试验(LAL)检测支气管肺泡灌洗液(BALF)在诊断革兰阴性杆菌肺炎中的作用.方法:LAL测定采用半定量法.BALF经纤维支气管镜导管法采集.结果:10例经细菌学确诊患者BALF内毒素水平均大于1∶16.细菌学确定的革兰阴性菌肺炎与BALF内毒素大于或等于1∶16阳性之间总符合率为90％(KAPPA系数0.67).经细菌学确诊的阴性菌肺炎组BALF内毒素单位(EU)为12.5*103EU/L,无肺炎组为1.8*103EU/L,差异有显著性(P＜0.01).结论:以LAL检测BALF为诊断阴性菌肺炎的一种快速、准确、简便的试验方法.“,”Objective:To determine the value of detection of endotoxin in bronchoalveolar lavage fluid(BALF)by limulus amebocyte lysate(LAL)test in the diagnosis of Gram negative bacterial pneumonia Methods:LAL was performed by using semi quantitative method,BALF was obtained by a catheter through fibroptic bronchoscope Results:The endotoxin levels in BALF exceeded 1∶16 from all 10 petients with microbiologically confirmed Gram negative bacterial pneumonia with a po...