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肠道既是人体消化和吸收器官,同时也是表面积最大的免疫器官。肠上皮处于机体与外界抗原接触的第一线,其表面表达一系列受体及免疫分子,在生理及病理情况下能分泌一系列细胞因子,在抗原提呈、感染防御等方面具有重要作用。每毫升大肠腔内容物中有1012种微生物,包括30个属、500个种。这些微生物局限在其天然栖居地-肠腔时,对维持机体健康有利。肠上皮的作用之一就是将这些微生物局限在肠腔。除了由细胞膜和细胞间紧密连接形成一道物理屏
Gut is both the body digest and absorb organs, but also the largest surface area of immune organs. Intestinal epithelium in the body and the external antigen in the first line of contact, the surface of a series of receptors and immune molecules expressed in the physiological and pathological conditions can secrete a series of cytokines in the antigen presentation, infection prevention plays an important role. There are 1012 microorganisms per milliliter in the contents of the large intestine, including 30 genera and 500 species. These microorganisms are limited in their natural habitat - the intestine, to maintain the health of the body. One of the roles of the gut epithelium is to confine these microorganisms to the intestine. In addition to the cell membrane and the cells are closely connected to form a physical screen