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目的探讨新活素治疗急性化学物中毒性心肌损伤合并心力衰竭的临床效果。方法选取急性化学物中毒性心肌损伤合并心力衰竭且治疗中应用新活素的30例患者作为观察组,选择同期常规方法治疗的急性化学物中毒性心肌损伤合并心力衰竭的30例患者作为对照组。比较两组患者治疗前后的心功能改善情况、治疗效果。结果观察组总有效率为90.0%(27/30),对照组总有效率为66.7%(20/30),观察组总有效率明显高于对照组,差异具有统计学意义(χ~2=4.812,P<0.05)。两组患者治疗前心功能各项指标比较差异无统计学意义(P>0.05)。治疗后,观察组心输出量(CO)、心脏指数(CI)及左室射血分数(LVEF)水平升高、氨基末端脑钠肽(NT-pro BNP)水平降低,且均优于对照组治疗后,差异具有统计学意义(P<0.05)。结论新活素在应用于急性化学物中毒性心肌损伤合并心力衰竭患者中效果显著,可以改善患者的心功能,快速缓解临床症状,提高临床治疗效果,安全有效,值得推广应用。
Objective To investigate the clinical effect of nesiritin on acute toxicant myocardial injury combined with heart failure. Methods Thirty patients with acute chemical toxic myocardial injury and heart failure who were treated with acute chemical poisoning myocardial injury combined with heart failure and new therapy were selected as the observation group. Thirty patients with acute myocardial injury and heart failure treated by conventional methods were selected as the control group . The improvement of cardiac function before and after treatment was compared between two groups of patients and the therapeutic effect was compared. Results The total effective rate was 90.0% (27/30) in the observation group and 66.7% (20/30) in the control group. The total effective rate in the observation group was significantly higher than that in the control group (χ ~ 2 = 4.812, P <0.05). There was no significant difference between the two groups in the indexes of cardiac function before treatment (P> 0.05). After treatment, the levels of cardiac output (CO), cardiac index (CI) and left ventricular ejection fraction (LVEF) increased and the level of NT-proBNP decreased in the observation group After treatment, the difference was statistically significant (P <0.05). Conclusion The application of neomycin is effective in patients with acute myocardial injury and acute myocardial infarction complicated with heart failure. It can improve the cardiac function, relieve the clinical symptoms and improve the curative effect effectively, which is worth popularizing and applying.