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本文报告8例混合结缔组织病(简称MCTD)。女7人,男1人。具有系统性红斑狼疮、硬皮病、多发性肌炎或皮肌炎的重叠表现,均有关节痛、肌炎、雷诺氏现象、发烧、硬皮病的皮肤改变及弥漫性非疤痕性脱发。7例有吞咽困难或食道蠕动减弱及神经精神异常,其中5例表现为唇舌或口周麻木,而且1例病重时有失语和神志不清,1例精神抑郁、淡漠,1例脑反应慢,1例伴发三叉神经痛。2例有肾损害,尿蛋白(+~++),RBC 0~2个/HP,管型0~1个/HP。2例肝大。1例脾大。1例心包炎。实验室检查8例血清
This article reports 8 cases of mixed connective tissue disease (referred to as MCTD). Female 7, male 1 people. It has the overlapping manifestations of systemic lupus erythematosus, scleroderma, polymyositis or dermatomyositis, all of which have joint pain, myositis, Raynaud’s phenomenon, skin changes of fever, scleroderma and diffuse non-scarring hair loss. Seven patients had dysphagia or decreased esophageal motility and neuropsychiatric abnormalities. Five of them showed tongue or perioral numbness, and one had aphasia and delirium when he was seriously ill. One patient was depressed, indifferent and one had slow brain response , 1 case with trigeminal neuralgia. 2 cases of renal damage, urinary protein (+ ~ +), RBC 0 ~ 2 / HP, tube 0 ~ 1 / HP. 2 cases of liver. 1 case of splenomegaly. 1 case of pericarditis. Laboratory examination of 8 cases of serum