论文部分内容阅读
[目的]探讨维生素E(VitE)拮抗甲醛(FA)引起的小鼠学习记忆能力改变的作用。[方法]将33只清洁级ICR小鼠随机分为4组:对照组(生理盐水组,8只)、FA(15mg/kg,9只)染毒组、VitE(100mg/kg,8只)组、FA(15mg/kg)+VitE(100mg/kg)组(8只)组。连续染毒7d后,用六臂放射状水迷宫检测小鼠的学习记忆能力。[结果]在学习期,与对照组相比,FA组潜伏期明显延长,差异有统计学意义(P﹤0.01);与FA组相比,FA+VitE组潜伏期明显缩短,差异有统计学意义(P﹤0.01)。在记忆期,与对照组相比,FA染毒组潜伏期明显延长,差异有统计学意义(P﹤0.01);与FA染毒组相比,FA+VitE组潜伏期明显缩短,差异有统计学意义(P﹤0.01),两期的各组间错误次数均无统计学差异。[结论]甲醛一定程度导致小鼠学习记忆能力下降,抗氧化剂对甲醛的神经毒性有保护作用。
[Objective] To investigate the effect of vitamin E on the change of learning and memory in mice induced by formaldehyde (FA). [Methods] Thirty-three ICR mice of clean grade were randomly divided into 4 groups: control group (8 rats in normal saline group), FA (15 mg / kg, 9 rats) Group, FA (15mg / kg) + VitE (100mg / kg) group (8). Seven consecutive days after exposure, six-arm radial water maze test mice learning and memory capabilities. [Results] Compared with the control group, the latent period of FA group was significantly longer than that of the control group (P <0.01). Compared with the FA group, the incubation period of FA + VitE group was significantly shorter (P <0.01) P <0.01). Compared with the control group, the incubation period of FA + VitE group was significantly longer than that of the control group (P <0.01), and the incubation period of FA + VitE group was significantly shorter than that of the FA group (P <0.01). There was no significant difference between the two groups in the number of errors. [Conclusion] Formaldehyde can reduce the ability of learning and memory in mice to a certain extent, and antioxidants have protective effect on the neurotoxicity of formaldehyde.