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大约一百年以前人们就发现体温增高可以使某些肿瘤消退。1884年Bruns氏报导一例晚期黑色素瘤感染丹毒后发热40℃以上,数日后肿瘤完全消退,并存活8年之久。1893年Coley氏报告了30例肿瘤伴有感染高热者。1918年有人复习文献中的肿瘤自然消退,166例癌中72例曾有高热严重感染或用发热治疗的历史,26例肉瘤中19例曾有发热感染或加热治疗史。1916年Percy曾报告宫颈癌用局部加温45℃以上的病例存活了3～7年。1932
About a hundred years ago, people discovered that an increase in body temperature can cause certain tumors to subside. In 1884, Bruns reported that a case of advanced melanoma had hyperthermia above 40°C after infection with erysipelas. After a few days, the tumor completely subsided and survived for 8 years. In 1893, Coley reported 30 cases of cancer associated with hyperthermia. In 1918, it was recalled that the tumors in the literature naturally subsided, and 72 of the 166 cancers had a history of severe fever or fever treatment. Of the 26 sarcomas, 19 had a history of fever infection or heat treatment. In 1916 Percy reported that cervical cancer survived for 3 to 7 years with local warming above 45°C. 1932