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目的评价血管紧张素转换酶抑制剂(ACEl)咪达普利、苯那普利对原发性高血压患者血管内皮功能的影响。方法采用随机、双盲、双模拟交叉对照法。将30例高血压患者随机分为2组,分别接受咪达普利-苯那普利或苯那普利-咪达普利顺序治疗。于治疗前后行血压、心率及血浆一氧化氮(NO)、内皮素-1(ET-1)测定。结果经咪达普利和苯那普利治疗10周后动脉血压明显降低,血浆NO有增加的趋势但统计学差异无显著性(P=0.237),血浆ET-1水平明显降低,统计学差异有显著性(P=0.001)。结论长效ACEI咪达普利和苯那普利在降低血压的同时降低循环ET-1水平,使内皮依赖的血管收缩功能减弱,使血管内皮功能得到一定的改善。
Objective To evaluate the effects of Imidapril and Benazepril on the endothelial function of patients with essential hypertension by angiotensin converting enzyme inhibitor (ACEl). Methods Randomized, double-blind, double-simulation cross-control method. Thirty patients with hypertension were randomly divided into two groups, receiving sequential treatment with imidapril-benazepril or benazepril-imidapril, respectively. Blood pressure, heart rate and plasma levels of nitric oxide (NO) and endothelin-1 (ET-1) were measured before and after treatment. Results The arterial blood pressure decreased obviously after 10 weeks of treatment with imidapril and benazepril, and the plasma NO had an increasing trend but no significant difference (P = 0.237) and plasma ET-1 level Significance (P = 0.001). CONCLUSION: The long-acting ACEIs, imidapril and benazepril can reduce the level of circulating ET-1 while decreasing blood pressure, weaken the function of endothelium-dependent vasoconstriction, and improve the endothelial function.