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干燥氢氧化铝凝胶是一种优良的抗酸药物,但是片剂的疗效和崩解度都比较差,本文探讨氢氧化铝片在制备工艺过程中各种条件对抗酸作用的影响。实验中采用能够反映胃部中和胃酸实际情况的体外实验方法(Armstrong法)作为评定抗酸作用的依据。取抗酸药片置于人工胃液中经过一定时间,取出反应液测定pH值,随即补加新的人工胃液,过一定时间再取出反应液测定pH值。如此反复操作。把实验结果绘制时间对PH值的中和曲线的图,借此观察抗酸作用的效果。提出以图中在一定
Dry aluminum hydroxide gel is an excellent antacid, but its efficacy and disintegration are relatively poor. This article discusses the effect of various conditions on the antacid effect of aluminum hydroxide during the preparation process. In the experiment, an in vitro experimental method (Armstrong method) that can reflect the actual condition of stomach and gastric acid was used as the basis for evaluating the antacid effect. Take antacid tablets placed in artificial gastric juice after a certain period of time, remove the reaction solution to measure the pH, then add a new artificial gastric juice, over a period of time and then remove the reaction solution was measured pH. So repeated. The results of the experiment were plotted against the time of PH neutralization curve to see the effect of antacid action. Proposed to be certain in the picture