Asymmetric dimethylarginine-induced oxidative damage leads to cerebrovascular dysfunction

• 作 者: Mushfiquddin Khan Inderjit Sin
• 机 构: Children’sResearchInstitute
• 出 处: 中国神经再生研究:英文版
• 发表日期: 2021年9期
• 关键词: OXIDATIVE MOIETY SYMMETRIC
• 基金项目: supported by the State of South Carolina Spinal Cord Injury Research Fund Board grant No.SCIRF#2017(to MK),the NIH grant No.R21NS114433(to JW and MK),the U.S.Department of Veterans Affairs grant No.RX

Asymmetric dimethylarginine(ADMA) and its enantiomer, symmetric dimethylarginine(SDMA), are naturally-occurring methylated metabolites of the L-arginine amino acid moiety of proteins followed by proteolysis(Grosse et al., 2020). These metabolites were fir