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在病原微生物的快速诊断法中原位DNA杂交等分子生物学手段虽日益增多,但免疫学方法目前仍是化脓性脑膜炎致病菌快速诊断的主要方法,不管原位杂交方法如何先进,如果菌体本身不存在,这种方法就不能发挥作用。相反,免疫学方法在抗原检出法中,其检测对象为可溶性的荚膜多糖抗原,此方法在诊断中不把菌体本身的存在作为绝对必要的条件,即使先使用抗菌素引起致病菌死亡的病例也可做致病菌诊断。流感杆菌、肺炎双球菌、脑膜炎双球菌、大肠杆菌及B族溶血性链球菌五大脑膜炎致病菌的共同特点是
In the rapid diagnosis of pathogenic microorganisms in situ DNA hybridization and other molecular biology means increasing, but immunological methods is still the main method of rapid diagnosis of purulent meningitis pathogens, no matter how advanced in situ hybridization method, if the bacteria The body itself does not exist, this method can not play a role. In contrast, immunological methods in the antigen detection method, the test object is soluble capsular polysaccharide antigen, this method does not diagnose the presence of the cell itself as an absolutely necessary condition, even if the first use of antibiotics cause death of pathogens Cases can also be done pathogenic bacteria diagnosis. Influenza bacteria, pneumococcus, meningococcus, Escherichia coli and B hemolytic streptococcus five common meningitis pathogens are