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氧氟沙星（ｏｆｌｏｘａｃｉｎ，ＯＦＬＸ）与头孢噻肟（ｃｅｆｏｔａｘｉｍｅ，ＣＴＸ）随机对照开放治疗肺部感染两组各３０例。年龄、性别、病种分类及病情轻重程度等资料无显著性差异（Ｐ＞０．０５）．结果显示两组有效率均为９６．６６％，细菌阴转率各为８６．６７％和８３．３３％，无显著性差异（Ｐ＞０．０５）。不良反应轻微，分别为３例（１０％）和４例（１３．３３％）。ＯＦＬＸ主要表现为精神兴奋和ＡＬＴ轻度增高，ＣＴＸ主要表现为静脉炎。体外抗菌活性表明两药对大多数革兰氏阴性菌和阳性茵均具有良好的抗菌活性。
Ofloxacin (OFLX) and cefotaxime (CTX) were randomly divided into two groups, 30 cases in each group. There was no significant difference in age, sex, disease classification and severity of illness (P> 0.05). The results showed that the effective rates of both groups were 96.66%, and the bacterial negative conversion rates were 86.67% and 83.33% respectively, with no significant difference (P> 0.05). Minor adverse reactions were 3 cases (10%) and 4 cases (13.33%). OFLX mainly manifested as mental excitement and mild increase of ALT, CTX mainly manifested as phlebitis. In vitro antibacterial activity shows that the two drugs have good antibacterial activity against most Gram-negative bacteria and positive bacteria.