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目的探讨小剂量rt-PA合用尼莫地平治疗急性脑梗死患者的疗效。方法选择发病3h内的急性脑梗死患者60例,随机分为对照组、rt-PA组和尼莫地平组各20例。全部患者给予常规治疗,rt-PA组还给予rt-PA治疗,尼莫地平组给予rt-PA+尼莫地平,并于治疗前和治疗后14d、30d采用NIHSS评价患者神经功能。结果治疗后14d、30drt-PA组、尼莫地平组的NIHSS评分明显优于对照组(p<0.05),且尼莫地平组在治疗后30d明显优于rt-PA组(p<0.05)。结论小剂量rt-PA合用尼莫地平治疗急性脑梗死可以有效改善急性缺血性脑损害患者的神经功能缺损,提高生活能力,改善生活质量,安全性较好。
Objective To investigate the effect of low-dose rt-PA combined with nimodipine in patients with acute cerebral infarction. Methods Sixty patients with acute cerebral infarction within 3h after onset were randomly divided into control group, rt-PA group and nimodipine group. All patients were given conventional therapy. Rt-PA was also given in rt-PA group and rt-PA plus nimodipine in nimodipine group. NIHSS was used to evaluate neurological function before and after treatment for 14d and 30d. Results On the 14th day after treatment, the NIHSS scores of 30drt-PA group and nimodipine group were significantly better than those of control group (p <0.05), and the nimodipine group was significantly better than rt-PA group 30d after treatment (p <0.05). Conclusion Low dose rt-PA combined with nimodipine in the treatment of acute cerebral infarction can effectively improve the patients with acute ischemic brain damage in neurological deficits, improve their ability to live, improve the quality of life, good safety.