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目的探讨唑来膦酸治疗老年骨质疏松症的疗效。方法选择2011年5月至2013年12月期间中老年骨质疏松患者6 0例,随机分为两组,每组30例。实验组单独应用5 mg唑来膦酸钠1次,两组同时服用阿法D3胶丸。比较治疗前后疼痛改善情况和骨密度变化。结果两组患者治疗前后腰背痛、体位更换痛及活动不便等均有改善,但治疗组改善明显,两组间比较差异有统计学意义(P<0.05)。治疗后实验组骨密度值显著提高(P<0.05),对照组骨密度值无明显增加(P>0.05)。结论结果表明唑来磷酸钠能明显缓解老年骨质疏松患者骨痛,并能有效增加骨密度。
Objective To investigate the efficacy of zoledronic acid in the treatment of senile osteoporosis. Methods Sixty patients with senile osteoporosis were selected from May 2011 to December 2013 and were randomly divided into two groups (n = 30 in each group). Experimental group alone 5 mg zoledronic acid sodium 1 time, two groups taking alfa D3 capsules. The changes of pain and bone mineral density before and after treatment were compared. Results Before and after treatment, the two groups had improvement of low back pain, pain of changing position and inconvenience of activity, but the treatment group improved significantly. There was significant difference between the two groups (P <0.05). After treatment, the BMD of the experimental group was significantly increased (P <0.05), while the BMD of the control group was not significantly increased (P> 0.05). Conclusion The results show that zoledronate can significantly relieve bone pain in elderly patients with osteoporosis and can effectively increase bone mineral density.