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本文观察了18例RB患儿、26例患儿父母、12例小儿对照、14例成人对照淋巴细胞染色体,同时分析6例患儿瘤细胞G带染色体。发现患儿染色体畸变频数高于正常小儿对照,患儿父母高于成人对照,遗传性RB高于非遗传性RB,患儿染色体畸变频数与其父母的相关系数r=0.415(P>0.10)。在患儿检出的脆性部位有fra(6)(cen)、fra(14)(q24)等。3例瘤组织中带有i(6p),1例有14q24断裂,显示了瘤细胞染色体改变与染色体上的脆性部位存在一致性。
In this paper, 18 cases of RB children, 26 children with parents, 12 cases of pediatric control, 14 cases of adult control lymphocyte chromosomes, while 6 cases of children with G cell chromosome. The frequency of chromosomal aberrations in children was higher than that in normal children. The children with parents were higher than those in adults. The hereditary RB was higher than that in non-hereditary RB. The correlation coefficient of chromosomal aberration frequency with his parents was 0.415 (P> 0.10). Fragile sites detected in children with fra (6) (cen), fra (14) (q24) and so on. Three cases of tumor tissue with i (6p), a case of 14q24 rupture, showing the tumor cell chromosome changes consistent with the brittle parts of chromosomes.