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活性氧自由基在造影剂肾病(Contrast-induced nephropathy,CIN)的发病机理中的作用,引起了人们对氧化抑制剂N-乙酰半胱氨酸(NAC)在CIN中的作用评估。目前有学者认为NAC可能通过抗氧化效应、抗自由基活性、诱导还原性谷胱甘肽(Glutathione,GSH)合成、扩张肾血管、抑制血管紧张素转化酶生成和稳定一氧化氮(NO)来减少造影剂对肾功能的损害,是一种安全、便宜的预防造影剂肾病的药物。尽管有很多临床试验证实NAC对预防CIN有一定作用,在大规模的多中心前瞻性随机对照试验完成之前,NAC的作用仍存在争议。本文就近年来乙酰半胱氨酸的抗氧化和细胞保护作用在造影剂肾病的预防方面的研究做一综述。
The role of reactive oxygen species in the pathogenesis of Contrast-induced nephropathy (CIN) has led to an assessment of the role of the N-acetylcysteine (NAC) in CIN. At present, some scholars think that NAC may induce anti-oxidation, anti-free radical activity, induce synthesis of glutathione (Glutathione, GSH), expand renal vessels, inhibit the production of angiotensin converting enzyme and stabilize nitric oxide Reduce the contrast agent on the renal function damage, is a safe, inexpensive medicine to prevent contrast nephropathy. Although there are many clinical trials that confirm the role of NAC in the prevention of CIN, the role of NAC remains controversial until large-scale, multicenter prospective randomized controlled trials are completed. In this paper, in recent years, the anti-oxidative and cytoprotective effects of acetylcysteine in the prevention of contrast agent nephropathy are reviewed.