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目的:通过对比的方法,评价奥美拉唑注射液和法莫替丁注射液在治疗上消化道出血的疗效和安全性。方法:将140例上消化道出血患者随机分成2组。实验组采用奥美拉唑注射液治疗70例,对照组采用法莫替丁注射液治疗70例。经过两周的治疗疗程,观察疗效。通过2独立样本t检验的统计学方法,对2组的疗效进行统计学分析。结果:在140例患者中,奥美拉唑注射液治疗组治愈率94.21%,法莫替丁注射液治疗组的治愈率为89.23%。经两独立样本t检验两两比较,奥美拉唑注射液治疗组的治愈率均高于单独用法莫替丁注射液组,P值为0.012(小于0.05)。在2组治疗过程中,患者均未出现严重不良反应,2周后,均对2组患者的大便常规进行隐血试验检测,发现奥美拉唑注射液治疗组大便隐血试验阳性率明显少于法莫替丁注射液治疗组,2组差异有统计学意义P值为0.017。结论:奥美拉唑注射液治疗上消化道出血的效果明显好于单独使用法莫替丁注射液的治愈率。同时,在采取两种不同治疗方法的治疗过程中,均无出现严重的不良反应情况发生。
Objective: To compare the efficacy and safety of omeprazole and famotidine injection in the treatment of upper gastrointestinal bleeding. Methods: 140 cases of upper gastrointestinal bleeding were randomly divided into two groups. 70 cases were treated with omeprazole injection in the experimental group and 70 cases were treated with famotidine injection in the control group. After two weeks of treatment, observe the effect. Statistical analysis was performed on the efficacy of the two groups by the statistical method of two independent samples t-test. Results: In 140 patients, the cure rate of omeprazole injection group was 94.21%, the cure rate of famotidine injection group was 89.23%. After two independent samples t-test comparisons, the cure rate of omeprazole injection group were higher than that of the famotidine alone group, P value was 0.012 (less than 0.05). In the two groups, no serious adverse reactions occurred in the patients. After two weeks, occult blood tests were performed on the stool routine in the two groups. The positive rate of stool occult blood test in the omeprazole injection group was significantly less than that in the two groups Mortality for the injection group, two groups, the difference was statistically significant P value of 0.017. Conclusion: The effect of omeprazole injection in the treatment of upper gastrointestinal bleeding was significantly better than that of famotidine alone. At the same time, there were no serious adverse reactions in the treatment of two different treatment methods.