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我们使用日本提供的单克隆抗-HBe(a)和(b)对RIA试剂盒研制过程中探讨了我国部分HBeAg阳性血清中存在新免疫结合位点问题。通过实验分析:该位点的特点为(1)RIA法双抗体夹心法用单抗-HBe(b)同时为包被/标记物时,有新位点的血清有较高计数。(2)该位点比b决定簇弱。(3)该位点与b决定簇有交叉免疫与a决定簇无明显交叉。该位点本质待深入研究。
We used the monoclonal anti-HBe (a) and (b) provided by Japan to explore the RIA kit development process in some of our HBeAg-positive serum in the presence of a new immune binding site. Experimental analysis: The characteristics of this locus are as follows: (1) When the RIA method double antibody sandwich method is coated / labeled simultaneously with the monoclonal antibody-HBe (b), the serum with the new locus has a higher count. (2) This locus is weaker than the b determinant. (3) There was no obvious crossover between this locus and the determinant of cluster b and a determinant. The nature of the site to be further studied.