Effective inhibition of expression of hepatitis B virus genes by DNAzymes

• 作 者: Jian-ErWo Xiao-LingWu Lin-FuZh
• 机 构: KeyLaboratoryofInfectiousDiseases,InstituteofInfectiousDiseases,MedicalSchool,InstituteofMedicalMicr
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2005年23期
• 关键词: 乙型肝炎病毒 DNA酶 病毒感染 治疗方法 基因表达 DNAzyme HBV Gene expression Inhibition
• 基金项目: Supported by the National Natural Science Foundation of China,No.30271183

AIM: To evaluate the inhibitory effects of DNAzymes on the expressions of hepatitis B virus (HBV) s (HBsAg) and e (HBeAg) in 2.2.15 cells, and to explore the potential therapeutic effects of DNAzymes on replication of HBV genome. METHODS: DNAzymes DrzBS a