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心肌纤维化是病毒性心肌炎向扩张型心肌病转化的重要环节,由心肌胶原代谢失衡引起,近年来基质金属蛋白酶及其组织抑制因子(MMPs/TIMPs)这一胶原降解系统比例失调造成病毒性心肌炎中胶原合成降解代谢紊乱并导致心肌发生纤维化。
Myocardial fibrosis is an important link of viral myocarditis into dilated cardiomyopathy. It is caused by imbalance of myocardial collagen metabolism. In recent years, the imbalance of matrix metalloproteinases and their tissue degradation factors (MMPs / TIMPs) causes the degradation of viral myocarditis Collagen in the synthesis of metabolic disorders and lead to myocardial fibrosis.