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目的探讨冻干重组人脑利钠肽对急性心肌梗死伴心力衰竭患者血管内皮功能的影响。方法选取2013年4月—2015年12月内蒙古医科大学附属医院收治的急性心肌梗死伴心力衰竭患者74例,采用随机数字表法分为对照组和观察组,每组37例。两组患者入院后均给予常规治疗,观察组患者在此基础上给予冻干重组人脑利钠肽静脉注射。比较两组患者治疗前后血流介导的内皮依赖性血管舒张功能(FMD)及血清一氧化氮(NO)、内皮素1水平。结果两组患者治疗前FMD比较,差异无统计学意义(P>0.05);观察组患者治疗后FMD高于对照组(P<0.05)。两组患者治疗前血清NO、内皮素1水平比较,差异无统计学意义(P>0.05);观察组患者治疗后血清NO水平高于对照组,血清内皮素1水平低于对照组(P<0.05)。结论冻干重组人脑利钠肽治疗可有效改善急性心肌梗死伴心力衰竭患者血管内皮功能。
Objective To investigate the effect of lyophilized recombinant human brain natriuretic peptide on the vascular endothelial function in patients with acute myocardial infarction and heart failure. Methods From April 2013 to December 2015, 74 patients with acute myocardial infarction and heart failure admitted to the Affiliated Hospital of Inner Mongolia Medical University were randomly divided into control group and observation group with 37 cases in each group. Two groups of patients were given conventional treatment after admission, the observation group was given intravenous injection of freeze-dried recombinant human brain natriuretic peptide on this basis. Blood flow-mediated endothelium-dependent vasodilation (FMD), serum nitric oxide (NO) and endothelin-1 levels were compared between the two groups before and after treatment. Results There was no significant difference in FMD between two groups before treatment (P> 0.05). The FMD in observation group was higher than that in control group (P <0.05). The levels of serum NO and ET-1 before treatment in the two groups were not significantly different (P> 0.05). The levels of serum NO in the observation group were higher than those in the control group, and the levels of endothelin-1 in the observation group were lower than those in the control group (P < 0.05). Conclusion Lyophilized recombinant human brain natriuretic peptide can effectively improve the vascular endothelial function in patients with acute myocardial infarction and heart failure.