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应用ＰＣＲ／ＲＦＬＰ方法对广东籍２２名正常人及２０名胰岛素依赖型糖尿病人（ＩＤＤＭ）进行了ＨＬＡ－ＤＱＢ１等位基因分型。结果：在ＤＱＢ１等位基因中未发现单独出现于ＩＤＤＭ的类型；全部等位基因中正常对照组与ＩＤＤＭ组间均无显著性差异；非Ａｓｐ－５７编码的ＤＱＢ１等位基因与广东籍ＩＤＤＭ病人不相关；广东籍ＩＤＤＭ的免疫遗传基因可能在ＨＬＡ－ＤＱＢ１以外的其它位点。
HLA-DQB1 alleles were genotyped by PCR / RFLP in 22 normal subjects and 20 insulin-dependent diabetes mellitus (IDDM) patients in Guangdong. RESULTS: No single type of IDDM was found in the DQB1 allele. There was no significant difference between the normal control group and the IDDM group in all the alleles. The non-Asp-57-encoded DQB1 allele was associated with IDDM patients in Guangdong Irrelevant; Guangdong IDDM immune genetic genes may be other than HLA-DQB1 other sites.