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目的探讨接种7价肺炎球菌结合疫苗(PCV7)预防肺炎球菌肺炎和重症肺炎的效果。方法用回顾性队列法,选取本市拱北辖区接种了PCV7的≥3月龄且<5岁儿童为PCV7组,未接种的为非PCV7组。调查两组的肺炎球菌肺炎和重症肺炎的发病情况。结果 PCV7组2 213人,肺炎球菌肺炎63例(2.9%),重症肺炎5例(0.2%);非PCV7组7 059人,肺炎球菌肺炎274例(3.9%),重症肺炎59例(0.8%)。PCV7组肺炎球菌肺炎发病率和重症肺炎发病率均较低。PCV7组对非PCV7组,肺炎球菌肺炎发病率和重症肺炎发病率比较,疫苗效率(VE)分别为27.4%和73.1%。PCV7组中,按标准免疫程序接种115人,肺炎球菌肺炎1人,发病率0.9%,无重症肺炎,补充免疫接种2 098人,肺炎球菌肺炎62人,发病率3.0%,重症肺炎5人(0.2%)。结论接种PCV7疫苗的肺炎和重症肺炎的保护效果好,尤其是对重症肺炎保护效果更好,肺炎发病率和重症肺炎的发病率都较低。
Objective To investigate the effect of vaccinating 7-valent pneumococcal conjugate vaccine (PCV7) on pneumococcal pneumonia and severe pneumonia. Methods Retrospective cohort method was used to select the PCV7 group and the non-PCV7 group which were ≥3 months old and < Investigation of the incidence of pneumococcal pneumonia and severe pneumonia in both groups. Results There were 2 213 patients in PCV7 group, 63 (2.9%) in pneumococcal pneumonia, 5 (0.2%) in severe pneumonia, 7 059 in non-PCV7 group, 274 (3.9%) in pneumococcal pneumonia and 59 (0.8% ). The incidence of pneumococcal pneumonia and severe pneumonia were lower in PCV7 group. PCV7 group of non-PCV7 group, the incidence of pneumococcal pneumonia and severe pneumonia compared to the vaccine efficiency (VE) were 27.4% and 73.1%. PCV7 group, according to the standard immunization program inoculated 115 people, pneumococcal pneumonia 1, the incidence rate of 0.9%, no severe pneumonia, supplementary immunization 2 098 people, 62 pneumococcal pneumonia, the incidence of 3.0%, severe pneumonia 5 ( 0.2%). Conclusion PCV7 vaccination pneumonia and severe pneumonia protective effect is good, especially for the protection of severe pneumonia better, the incidence of pneumonia and severe pneumonia are low incidence.