论文部分内容阅读
对Ｔｏｐｌｉｓ寻搜法加以改进合成５个化合物，找到６氨基１，２双（对氯苯）己烯１化合物氨基上不同取代基的“合成终点”。用分子图形学的方法对其结构与活性的关系进行研究，结果表明药物的亲脂部分处于ＣａＭ活性部位的疏水“口袋”中，而亲水部分处于“口袋”的外部，氨基上的取代基对于药物与ＣａＭ的结合影响不大。
Toplis search method to be improved synthesis of five compounds, to find 6 amino-1,2-bis (p-chlorophenyl) hexene 1 compound amino substituents on the “end of the synthesis.” Molecular structure was used to study the relationship between structure and activity. The results showed that the lipophilic part of the drug was located in the hydrophobic “pocket” of CaM active site while the hydrophilic part was outside the “pocket”. The substitution of the amino group For the combination of drugs and CaM little effect.