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目的 :前文已报道 ,Ｍ细胞ＲＡＷ2 64 7在ＬＰＳ预处理后诱导了致敏和耐受 ,提示ＬＰＳ预处理引起细胞内参与反应的信号转导分子或效应分子发生了某种变化。已知 [Ｃａ2 +]ｉ在白细胞活化中的重要性以及静态 [Ｃａ2 +]ｉ与Ｍ反应性有密切关系 ,因此我们推测ＬＰＳ预处理可
PURPOSE: It has been previously reported that the sensitization and tolerance of M2 cell RAW2647 induced by LPS pretreatment suggests that LPS preconditioning causes some changes in intracellular signaling molecules or effector molecules involved in the response. It is known that the importance of [Ca2 +] i in leukocyte activation as well as the static [Ca2 +] i and M reactivity are closely related, so we hypothesize that LPS pretreatment may