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目的：对螺旋藻免疫调节作用的机理进行研究。方法：采用竞争性蛋白结合分析法，研究螺旋藻多糖（ Ｓｐｉｒｕｌｉｎａ ｐｌａｔｅｎｓｉｓ ｐｏｌｙｓａｃｃｈａｒｉｄｅｓ，ＳＰＰ） 对小鼠脾细胞中第二信使环腺苷酸（ｃＡＭＰ） 浓度的影响。结果：ＳＰＰ可剂量依赖性引起小鼠脾细胞中ｃＡＭＰ浓度的升高。结论：ＳＰＰ免疫调节作用的重要机制之一是对脾细胞中第二信使ｃＡＭＰ浓度的影响。关键词 螺旋藻多糖，环磷酸腺苷，脾细胞
Objective: To study the mechanism of immunomodulatory effect of Spirulina. Methods: Competitive protein binding assay was used to study the effect of Spirulina platensys polysaccharides (SPP) on the concentration of cAMP in second messenger of mouse spleen cells. Results: SPP caused a dose-dependent increase in cAMP concentration in mouse splenocytes. Conclusion: One of the important mechanisms of SPP immunomodulatory effect is the effect of cAMP concentration on the second messenger in spleen cells. Key words spirulina polysaccharide, cyclic adenosine monophosphate, spleen cells