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1966年Bircher等首先报告使用乳果糖治疗肝性脑病的经验,以后相继有许多报告证实了其疗效,因而在美国、欧洲及日本应用甚广。1985年,我国由陕西省西安第四药厂试制成功了国产的乳果糖。作用机制乳果糖是人工合成的含酮双糖,其结构为4-O-B-D 吡喃半乳糖-D-果糖。乳果糖经口服进入肠道后,在肠道乳酸菌属与类链球菌作用下,水解为乳酸、乙酸及少量甲酸;从定量观点看,1分子乳果糖可生成4
In 1966, Bircher et al first reported on the experience of using lactulose to treat hepatic encephalopathy. Since then, many reports have confirmed its curative effect and are widely used in the United States, Europe and Japan. In 1985, our country successfully made the homemade lactulose by the trial of Xi’an No.4 Pharmaceutical Factory in Shaanxi Province. Mechanism of action Lactulose is a synthetic keto-disaccharide containing 4-O-B-D galactopyranosyl-D-fructose. Lactulose by oral into the intestine, in the intestinal Lactobacillus and Streptococcus mutans under the action of hydrolysis of lactic acid, acetic acid and a small amount of formic acid; quantitative point of view, a molecular lactulose can generate 4