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２月龄雄性Ｗｉｓｔａｒ大鼠去势后补肾壮骨药给药３个月，发现补肾壮骨药除具有性激素和促性腺激素样作用，可以显著升高降钙素含量，降低甲状旁腺素含量，降低血钙和羟脯氨酸含量，提高碱性磷酸酶活性。提示补肾壮骨药能抑制模型动物骨量丢失，促进成骨作用。
After 2 months old male Wistar rats were castrated and Bushen Zhuanggu was administered for 3 months, the addition of Bushen Zhuanggu was found to have a sex hormone and gonadotropin-like effect, which could significantly increase the content of calcitonin and reduce the content of parathyroid hormone. , Reduce blood calcium and hydroxyproline content and increase alkaline phosphatase activity. Tips Bushen Zhuanggu medicine can inhibit the loss of bone mass in model animal and promote the bone formation.