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黄连素即小蘖碱(Berberine)有良好的抗菌作用,抗菌谱较广,而副作用和毒性较其他抗菌西药为低,且细菌对它不易产生抗药性。目前广泛用于痢疾、肠炎及其他敏感性细菌感染的治疗。目前我国生产黄连素主要还是从含有小蘖碱的中草药中提取,人工合成黄连素的工作尚在试验阶段。由于用来提取黄连素的中草药如黄连及三颗针等较为缺乏,致使黄连素存在着供不应求的情况。为解决临床上用药的急需,我们开展了用离子交换法从广东地区药源丰富的华南十大功劳中提取黄连素的研究工作。我们的工作得到了市科委和学院科研组的大力支持。
Berberine Berberine has a good antibacterial effect, broad spectrum of antibacterial, and side effects and toxicity is lower than other antibacterial western medicine, and bacteria are not easy to produce resistance to it. It is widely used for the treatment of dysentery, enteritis and other sensitive bacterial infections. At present, the production of berberine in China is mainly extracted from berberine-containing Chinese herbal medicines. The artificial synthesis of berberine is still in the experimental stage. Due to the lack of Chinese herbal medicines such as berberine and three needles used to extract berberine, the supply of berberine is in short supply. In order to solve the urgent need for clinical use of drugs, we carried out research on the use of ion exchange method to extract berberine from the rich source of raw materials in southern China. Our work has received strong support from the Science and Technology Commission of the Municipal Committee of Science and Technology.