Synthesis and biological evaluation of ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylates aga

来源 :Chinese Chemical Letters | 被引量 : 0次 | 上传用户:xiaofei3310
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A series of ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylates were designed and synthesized.Their structures were confirmed by ~1H NMR,~(13)C NMR,IR and HRMS.The biological activities were primarily evaluated against Eimeria tenella according to Anticoccidial Index(ACI) method in vivo.The results showed that compounds 5e,5f and 5i exhibited anticoccidial activities against E.tenella at 27 mg kg~(-1). A series of ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylates were designed and synthesized. The structures were confirmed by ~ 1H NMR, ~ (13) C NMR, IR and HRMS. against Eimeria tenella according to Anticoccidial Index (ACI) method in vivo. These results showed that compounds 5e, 5f and 5i exhibited anticoccidial activities against E. tenella at 27 mg kg -1.
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