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目的 探讨硬膜外镇痛对产妇血清催乳素 (prolactin ,PRL)的影响。方法 选择 5 0例产妇随机分为镇痛组(E组 )和对照组 (C组 )。E组在宫口开至 3～ 4cm时开始硬膜外镇痛 ,镇痛药为 0 12 5 %布比卡因 (每ml含 2 μg芬太尼 ) ,C组按产科常规处理。分别在产前、产后 2h及产后 2 4h抽取母亲静脉血采用放免法测定血清PRL ,并观察镇痛效果及哺乳情况。结果 硬膜外镇痛效果良好 ,两组产妇血清PRL及泌乳始动时间差异无显著性。结论 硬膜外低浓度布比卡因复合芬太尼行无痛分娩镇痛效果良好 ,对血清PRL及泌乳始动时间无明显影响
Objective To investigate the effect of epidural analgesia on serum prolactin (PRL). Methods Fifty maternal women were randomly divided into analgesic group (E group) and control group (C group). Group E started epidural analgesia when the cervix was open to 3 ~ 4 cm, analgesics were 0,125% bupivacaine (2 μg fentanyl per ml), and group C was routinely obeyed. Maternal venous blood samples were taken from prenatal, postnatal 2h and postnatal 24 h, respectively. Serum PRL levels were measured by radioimmunoassay and the analgesic effect and nursing status were observed. Results The results of epidural analgesia were good. There was no significant difference in PRL and lactation time between the two groups. Conclusions Epidural low-concentration bupivacaine combined with fentanyl showed good pain-relieving analgesia and had no significant effect on serum PRL and lactation time