首乌复方对兔红细胞膜Ca~(2+),Mg~(2+)-ATPase活性的影响

• 作 者: 段江燕 张金红 许乃寒 刘静 高秀梅 张伯礼
• 机 构: 南开大学分子生物学研究所!天津300071,南开大学分子生物学研究所!天津300071,南开大学分子生物学研究所!天津300071,天津师大生物系!九七级学生,天津中医学院中医研究所,天津中医学院中医
• 出 处: 中草药
• 发表日期: 2000年08期
• 关键词: ATPase Ca Mg 首乌 首乌复方 胆固醇 Ca~(2+) Mg~(2+)-ATPase 兔红细胞 兔血

研究首乌复方对高血脂兔红细胞膜 Ca2 + ,Mg2 + - ATPase活性的影响。实验结果表明 ,高脂饲料能显著地引起兔血浆中总胆固醇积累 ;也使兔血红细胞膜 Ca2 + ,Mg2 + - ATPase的基础活性降低近 2 0 % ;而依赖钙调素(Ca M)激活的 Ca2 + ,Mg2 + - ATPase的活性则是正常兔的 144 %。首乌复方不但能有效地阻止血液中胆固醇的积累 ;而且还能使 Ca2 + ,Mg2 + - ATPase的基础活性基本恢复正常水平

To study the effects of Shouwu compound on Ca2 + and Mg2 + - ATPase activity of erythrocyte membrane in hyperlipidemic rabbits. The experimental results showed that high-fat diet can significantly induce the accumulation of total cholesterol in rabbit plasma; it also reduced the basal activity of Ca2 + and Mg2 + - ATPase in rabbit red blood cell membrane by nearly 20%; and it was dependent on the activation of calmodulin (Ca M). The activity of Ca2 + and Mg2 + - ATPase was 144% of normal rabbits. Shouwu compound can not only effectively prevent the accumulation of cholesterol in the blood, but also restore the basic activity of Ca2+, Mg2+-ATPase to normal levels.