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目的：观察杀菌性／通透性增加蛋白（ＢＰＩ）模拟肽对内毒素（ＬＰＳ）攻击所致小鼠死亡的保护作用。方法：以一个ＬＤ５０的ＬＰＳ（２０ｍｇ·ｋｇ－１）静脉注射攻击小鼠，分别于ＬＰＳ攻击后２０ｓ内静脉注射不同剂量的ＢＰＩ模拟肽；于ＬＰＳ攻击前及攻击后不同时间内分别静脉注射５ｍｇ·ｋｇ－１和１０ｍｇ·ｋｇ－１的ＢＰＩ模拟肽，以观察ＢＰＩ模拟肽对ＬＰＳ攻击所致小鼠死亡的保护作用、ＢＰＩ模拟肽对ＬＰＳ攻击小鼠死亡保护作用的时效关系及ＢＰＩ模拟肽对ＬＰＳ攻击小鼠死亡的预防作用。结果：ＢＰＩ模拟肽对ＬＰＳ所致小鼠死亡有明显的保护作用及预防作用，并有一定的量效关系及时效关系。结论：ＢＰＩ模拟肽，不仅保留了ＢＰＩ特异性中和ＬＰＳ的特性，而且对ＬＰＳ攻击小鼠具有更强的保护作用
Objective: To observe the protective effect of bactericidal / permeability-increasing protein (BPI) peptidomimetic on the death of mice induced by endotoxin (LPS) challenge. METHODS: Mice were challenged with an LD50 of 20 mg · kg-1 at a dose of 50 mg · kg-1 and intravenous injection of BPI at different doses within 20 s after LPS challenge. Before and after LPS challenge, 5 mg · Kg -1 and 10 mg · kg -1 BPI peptide to observe the protective effect of BPI mimic peptide on LPS challenge-induced mouse death, the relationship between BPI mimetic peptide and LPS-challenged mouse and the effect of BPI mimic peptide Preventive effect on the death of LPS challenge mice. Results: BPI peptide showed a significant protective and preventive effect on the death of mice induced by LPS, and had some dose-effect and time-effect relationship. CONCLUSION: The BPI mimetic peptide not only retains the characteristic of BPI-specific neutralization of LPS, but also has a stronger protective effect on LPS-challenged mice