论文部分内容阅读
目的:观察不同剂量甲氨蝶呤保守治疗异位妊娠的临床疗效。方法:将2001年6月～2011年5月早期未破裂异位妊娠患者210例随机分为A组、B组和C组,每组各70例。A组给予甲氨蝶呤0.4 mg.kg-1.d-1肌内注射,连用5天;B组给予甲氨蝶呤1.0 mg.kg-1.d-1单次肌内注射;C组给予甲氨蝶呤1.0 mg/kg肌内注射,隔日1次,四氢叶酸0.1 mg/kg肌内注射,隔日1次,共4次。观察3组血β-人绒毛膜促性腺激素(β-HCG)水平变化,并应用B超复查异位病灶的变化。结果:治疗1周后血β-HCG下降幅度:C组>B组>A组;血β-HCG水平下降至正常时间:C组0.05)。结论:甲氨蝶呤不同剂量、不同给药方式保守治疗异位妊娠均有一定疗效,但大剂量、多次给药配合解毒治疗,作用更迅速。
Objective: To observe the clinical efficacy of different doses of methotrexate conservative treatment of ectopic pregnancy. Methods: 210 patients with early ectopic pregnancy without rupture between June 2001 and May 2011 were randomly divided into group A, group B and group C, with 70 cases in each group. Group A was given intraperitoneal injection of methotrexate 0.4 mg.kg-1.d-1 for 5 days; group B was given intramuscular injection of methotrexate 1.0 mg.kg-1.d-1; Group C Methotrexate 1.0 mg / kg given intramuscularly, every other day, tetrahydrofolate 0.1 mg / kg intramuscular injection, every other day, a total of 4 times. The levels of β-HCG in the three groups were observed, and the changes of ectopic lesions were examined by B ultrasound. Results: After 1 week of treatment, the decline of β-HCG in blood was: group C> group B> group A; The level of serum β-HCG decreased to normal time: group C 0.05). CONCLUSION: Methotrexate has different effects on conservative treatment of ectopic pregnancy with different dosage and dosage. However, the combination of dex treatment and multiple doses of methotrexate has a rapid effect.