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目的 :探讨米非司酮配伍米索前列醇在中期妊娠引产中的作用。方法 :对 10 0例妊娠 13～ 2 7周孕妇有引产指征者 ,随机分为两组 ,研究组 5 0例 ,口服米非司酮 2 0 0mg ,分 2次口服 ,第 2次服米非司酮后阴道穹窿置米索 60 0ug ;对照组 5 0例 ,采用经腹羊膜腔内注入利凡诺 10 0mg。结果 :研究组平均引产时间为 10 .1± 5 .62h ,平均出血量为 3 9.4± 16.6ml,胎盘完整 3 2例 ,占 64 % ;对照组平均引产时间为 45 .3± 2 3 .3h ,出血量平均为 13 1.7± 5 0 .8ml,两者差异有显著意义(p <0 .0 1)。研究组无胃肠道反应 ,仅需住院 1d ,而对照组需住院 5～ 7d。结论 :米非司酮联合米索用于中期妊娠引产时间短 ,出血量少 ,成功率高 ,且副作用少 ,值得临床推广应用。
Objective: To explore the role of mifepristone and misoprostol in inducing labor in mid-term pregnancy. Methods: One hundred and ten pregnant women with gestational age from 13 to 27 weeks were included in this study. They were randomly divided into two groups: study group 50 cases, oral mifepristone 200 mg orally 2 times, Vaginal fornixin vaginal fornix 60 0ug; control group of 50 cases, the use of transabdominal amniotic injection of rivanol 10 0mg. Results: The average induction of labor time was 10.1 ± 5.62h, the average amount of bleeding was 3 9.4 ± 16.6ml, the complete placenta 32 cases, accounting for 64%; the control group, the average induction of labor was 45.3 ± 23.3h , The average amount of bleeding was 13 1.7 ± 5.0 0.8ml, the difference was significant (p <0.01). The study group had no gastrointestinal reaction, only hospitalized 1d, while the control group required hospitalization 5 ~ 7d. Conclusion: Mifepristone combined with misoprostol for misoprostol in the second trimester has the advantages of short induction of labor, less bleeding, high success rate and less side effects, which is worthy of clinical application.