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目的:分析抗环瓜氨酸肽(CCP)抗体对类风湿关节炎(RA)的诊断和评估意义,探讨抗CCP抗体与RA的病情活动度、关节侵蚀的关系。方法:用ELISA检测32例RA患者血清和关节液中的抗CCP抗体,并测定类湿因子(RF),记录RA患者的一些临床参数。对检测结果及临床参数进行统计分析。结果:抗CCP抗体阳性组与阴性组相比,年龄、关节肿胀个数、关节疼痛个数、DAS28、血沉及CRP等没有显著性差异(P>0.05);类风湿因子的阳性率在两组间的差异有统计学意义(P<0.05)。抗CCP抗体与年龄、关节肿胀个数、关节疼痛个数、DAS28、ESR和CRP等相关无显著性差异;抗CCP抗体与RF因子呈明显相关(r=0.639,P=0.001)。DAS28评分与关节肿胀个数、关节疼痛个数、DAS28、ESR和CRP显著相关,与年龄因素呈正相关,与类风湿因子的相关无统计学意义。结论:抗CCP抗体对RA的预后有一定的评估作用。
Objective: To analyze the diagnostic and evaluation significance of anti-cyclic citrullinated peptide (CCP) antibody on rheumatoid arthritis (RA) and to explore the relationship between anti-CCP antibody and disease activity and joint erosion. Methods: The anti-CCP antibodies in serum and synovial fluid of 32 patients with RA were detected by ELISA. The wet-like factor (RF) was measured and some clinical parameters of RA patients were recorded. The test results and clinical parameters for statistical analysis. Results: There was no significant difference in the age, the number of joint swelling, the number of joint pain, DAS28, erythrocyte sedimentation rate and CRP among the anti-CCP positive group and the negative group (P> 0.05). The positive rate of rheumatoid factor in the two groups The difference was statistically significant (P <0.05). There was no significant difference between anti-CCP antibody and age, the number of joint swelling, the number of joint pain, DAS28, ESR and CRP. The anti-CCP antibody was significantly correlated with RF (r = 0.639, P = 0.001). The score of DAS28 was significantly correlated with the number of joint swelling, the number of joint pain, DAS28, ESR and CRP, with age, but not with rheumatoid factor. Conclusion: The anti-CCP antibody has a certain evaluation of the prognosis of RA.