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采用电生理学与行为学的结合方法，通过慢性埋植微电极技术，观察到大鼠在明暗分辨学习的建立过程中，海马 ＣＡ_１区不同传入突触上（Ｓｃｈａｆｆｅｒ－ＣＡ_１与 Ｐｅｒｆｏｒａｎｔ Ｐａｔｈ－ ＣＡ_１）均同步产生传递效能的长时程增强（ＬＴＰ）变化，在产生这一习得性ＬＴＰ的幅度上，ＰＰ－ＣＡ_１大于Ｓｃｈ－ＣＡ_１．而对照的假性训练动物却均未见到有这种变化，差异显著（Ｐ＜０．００１）．结果表明ＣＡ区的不同传入通路在参与学习中均协同地产生突触效能变化，这为从神经回路角度探讨学习与记忆的神经机制提供有意义的证据，作者并就此予以讨论．
By means of electrophysiological and behavioral methods, chronic implanted microelectrode technique was used to observe the effects of Schaffer-CA_1 and Perforant Path-CA_1 on the synapses of hippocampal CA1 region during the establishment of light and dark learning, Both produced long-term potentiation (LTP) changes in transmission performance, and the magnitude of this learned LTP was greater for PP-CA_1 than for Sch-CA_1. The control of the pseudo-training animals, but did not see any such changes, the difference was significant (P <0.001). The results show that the different afferent pathways in CA area cooperatively produce synaptic potency changes during the learning process, which provides meaningful evidence for exploring the neural mechanism of learning and memory from the perspective of neural circuits. The authors discuss this issue.